- Rekrutierung läuftA phase 1 study evaluating the safety, tolerability and pharmacokinetics of AMG 757 in subjects with small cell lung cancerMolekulare Marker
- Rekrutierung läuft
A First –in Human Phase I, non-randomized, open-label, multicenter dose escalation trial of BI 764532 administered by repeated intravenous infusions in patients with Small Cell Lung Carcinoma and other neuroendocrine neoplasms expressing DLL3.
Molekulare Marker - Rekrutierung läuftA first-in-human, two-part, open-label, clinical study to assess the safety, tolerability and activity of intravenous doses of ICT01 as monotherapy and in combination with an immune checkpoint inhibitor, in patients with advanced-stage, relapsed/refractory cancer (EVICTION Study)Indikationen
- Brustkrebs (Mammakarzinom)
- Bösartige Erkrankungen des oberen Verdauungstraktes (Oesophagus, Magen, gastrooesophagealer Übergang)
- Karzinom des gastrooesophagealen Übergangs
- Magenkarzinom
- Weitere Tumoren des Verdauungstraktes (z.B. Gastrointestinale Stromatumoren, GIST)
- Lungentumoren
- Nicht-kleinzelliges Bronchialkarzinom (NSCLC)
- Kopf/Hals Tumoren
- Kopf-Hals-Malignome
- Hauttumoren
- Malignes Melanom
- Lymphome inkl. Morbus Hodgkin, Multiples Myelom und Chronisch Lymphatischer Leukämie (CLL)
- Non-Hodgkin Lymphome (inkl. Chron. Lymphat. Leukämie, CLL)
- Leukämien
- Akute lymphatische Leukämie und Burkitt-Lymphom (ALL)
- Akute myeloische Leukämie (AML)
- Rekrutierung läuftA multicenter open-Label, dose-escalating, Phase I Trial with GEM333, a CD33 targeted bispecific antibody engaging T-cells in relapsed or refractory acute myeloid leukemiaIndikationenMolekulare Marker
- Rekrutierung läuftA Multicenter, Open-label, Dose-escalating, Phase I Trial with GEM3PSCA, a PSCA Targeted Bispecific Antibody Engaging T-cells, in Patients with Progressive Disease after Standard Systemic Therapy in Cancers with Positive PSCA MarkerMolekulare Marker
- Rekrutierung läuftPhase 1 study evaluating genetically modified autologous T cells expressing a T cell recepter recognizing a cancer/germline Antigen in patients with recurrent and/or refractory solid Tumors (ACTengine IMA203-101)Target: PRAME
- Rekrutierung läuft
This is an open-label, multi-center, Phase I study to investigate the safety and tolerability of REGN1979, an Anti-CD20 X Anti CD3 Bispecific Monoclonal Antibody, in patients with CD20+ B-Cell Malignancies previously treated with CD20- Directed Antibody Therapy
Molekulare Marker - Rekrutierung läuftMultizentrische, offene Phase I Studie mit Dosissteigerungen für die Behandlung von Patienten mit CD123 positiven hämatologischen und lymphatischen Malignomen mittels gentechnisch veränderten T-Zellen, die universelle chimäre Antigen-Rezeptoren (UniCAR02-T) auf der Oberfläche tragen, und in Kombination mit einem CD123-spezifischen Zielmodul (TM123) verabreicht werden Cellex UC02-123-01Molekulare Marker
- Rekrutierung läuft
Multicenter, Open-label, Adaptive Design Phase I Trial with Genetically Modified T-cells Carrying Universal Chimeric Antigen Receptors (UniCAR02-T) in Combination with PSMA peptide Target Module (TMpPSMA) for the Treatment of Patients with Progressive Disease after Standard Systemic Therapy in Cancers with Positive PSMA Marker
IndikationenMolekulare Marker