A Phase 1b StudyEvaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 193in Combination With other Therapies in Subjects With Advanced Gastrointestinal,Biliary Tract, or Pancreatic Cancers With Homozygous MTAP-deletion

Subprotocol A: AMG 193 in Combination withGemcitabine, Cisplatin, and Pembrolizumab in Subjects with Advanced BTC WithHomozygous MTAP-deletion

Subprotocol B: AMG 193 in Combination withmFOLFIRINOX or with Gemcitabine and Nab-paclitaxel in Subjects with AdvancedPDAC with Homozygous MTAP-deletion