Studieninformationen
Kurztitel:
ADRIATIC
Beschreibung:
A Phase III, Randomized, Double-blind, Placebo-controlled, Multi-center, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation Treatment for Patients with Stage I-III Limited Disease Small-Cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy (ADRIATIC)
Studiendesign:
Phase III, Therapeutisch, Peer Reviewed, Monozentrisch, National
Therapielinien:
Zweitlinie
Alter:
>= 18 Jahre
Ein-/Ausschlusskriterien:
Inclusion criteria: Histologically or cytologically documented limited-stage small cell lung cancer (stage I-III). Received 4 cycles of chemotherapy concurrent with radiotherapy, which must be completed within 1 to 42 days prior to randomization and the first dose of IP. Chemotherapy must contain platinum and IV etoposide. Radiotherapy must be either total 60-66 Gy over 6 weeks for the standard QD regimen or total 45 Gy over 3 weeks for hyperfractionated BD schedules. PCI may be delivered at the discretion of investigator and local standard of care, and must be conducted after the end of cCRT and completed between 1 to 42 days to first dose of IP. 4 .Have not progressed following definitive concurrent chemoradiation 5 .Life expectancy ≥ 12 weeks at Day 1. 6. ECOG 0 or 1 at enrolment. Exclusion criteria: Extensive-stage SCLC Active or prior documented autoimmune or inflammatory disorders Uncontrolled intercurrent illness, including but not limited to interstitial lung disease. Active infection including tuberculosis, HIV, hepatitis B and C Patients who received sequential chemotherapy and radiotherapy (no overlap of RT with chemotherapy)
NCT-Nummer:
Eudract-Nummer:
Studienaktive Standorte
Universitätsklinikum Würzburg
97080 Würzburg
Interdisziplinäres Studienzentrum mit Early Clinical Trial Unit
Rekrutierung läuft
Herr Dr. Jens Kern
jens.kern@missioklinik.de
Frau PD Dr. Barbara Deschler-Baier
Deschler_B@ukw.de